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Understanding the mechanism of blood vessel formation has been an important subject in recent medical research. Various experiments and models have been proposed, yet fully understanding the mechanism has been challenging. This paper is meant to be a brief description of experimental results and methods of modeling the blood vessel formation.
Models are compared with experimental data for the process of both vasculogenesis and angiogenesis to discuss how physical assumptions in the models lead to the understanding of biological mechanism.
The human body has a complex circulatory system. Blood circulates in the entire body through arteries, capillaries, the heart and veins. It is these blood vessels that enable client exchange of oxygen and nutrients and the removal of waste products in the body. For this reason, blood vessels play a role in virtually every medical condition. Understanding the blood-vascular system and its formation is an important task, because it will directly lead to the cure of various diseases.
Formation of blood vessels begins in the early stage of embryonic development, and is achieved by two successive processes: vasculogenesis and angiogenesis.
Blood vessel formation originates in an aggregations of cells called blood islands that form in the embryonic yolk sac, a membranous sac attached to an embryo.